IGF1R - insulin like growth factor 1 receptor Gene

Also Known as IGFR; CD221; IGFIR; JTK13

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3480

About IGF1R

Cytogenetic location: 15q26.3 Genomic coordinates (GRCh38): 15:98,648,539-98,964,530 (from NCBI)

This gene has 17 transcripts (splice variants), 276 orthologues, 53 paralogues and is associated with 4 phenotypes. Ubiquitous expression in kidney (RPKM 8.9), ovary (RPKM 8.7) and 24 other tissues.

Summary

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

IGF1R Products (10)

mRNA	Protein	Name
XM_017022137.2	XP_016877626.1	insulin-like growth factor 1 receptor isoform X1
NM_000875.5	NP_000866.1	insulin-like growth factor 1 receptor isoform 1 precursor
XM_047432444.1	XP_047288400.1	insulin-like growth factor 1 receptor isoform X4
XM_047432442.1	XP_047288398.1	insulin-like growth factor 1 receptor isoform X2
XM_047432445.1	XP_047288401.1	insulin-like growth factor 1 receptor isoform X5
XM_011521516.3	XP_011519818.1	insulin-like growth factor 1 receptor isoform X6
NM_152452.1
XM_011521517.3	XP_011519819.1	insulin-like growth factor 1 receptor isoform X7
NM_001291858.2	NP_001278787.1	insulin-like growth factor 1 receptor isoform 2 precursor
XM_047432443.1	XP_047288399.1	insulin-like growth factor 1 receptor isoform X3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	11448933	GOA
enables insulin binding	IPI IPI: Inferred from physical interaction	8452530	GOA
enables insulin receptor binding	IDA IDA: Inferred from direct assay	8452530	GOA
enables insulin receptor substrate binding	IPI IPI: Inferred from physical interaction	7541045	GOA
enables insulin-like growth factor I binding	IDA IDA: Inferred from direct assay	19578119	GOA
enables insulin-like growth factor I binding	IPI IPI: Inferred from physical interaction	8452530	GOA
enables insulin-like growth factor binding	IDA IDA: Inferred from direct assay	1846292	GOA
enables insulin-like growth factor receptor activity	IDA IDA: Inferred from direct assay	7679099	GOA
enables phosphatidylinositol 3-kinase binding	IPI IPI: Inferred from physical interaction	7541045	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7541045	GOA
enables protein transporter activity	IMP IMP: Inferred from mutant phenotype	16306401	GOA
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	7679099	GOA
enables protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	11884589	GOA
enables structural molecule activity	IDA IDA: Inferred from direct assay	1846292	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in amyloid-beta clearance	IMP IMP: Inferred from mutant phenotype	19406747	GOA
involved in cellular response to amyloid-beta	IGI IGI: Inferred from genetic interaction	22635104	GOA
involved in immune response	IMP IMP: Inferred from mutant phenotype	16886151	GOA
involved in insulin-like growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	7679099	GOA
involved in negative regulation of MAPK cascade	IDA IDA: Inferred from direct assay	12556535	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	12556535	GOA
acts upstream of or within peptidyl-tyrosine autophosphorylation	IMP IMP: Inferred from mutant phenotype	19545541	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	12138094	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12138094	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	7692086	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	1846292	GOA
involved in regulation of JNK cascade	IDA IDA: Inferred from direct assay	12556535	GOA
involved in transcytosis	IMP IMP: Inferred from mutant phenotype	16306401	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of alphav-beta3 integrin-IGF-1-IGF1R complex	IDA IDA: Inferred from direct assay	19578119	GOA
located in intracellular membrane-bounded organelle	IDA IDA: Inferred from direct assay	8452530	GOA
located in membrane	IDA IDA: Inferred from direct assay	8452530	GOA
part of protein kinase complex	IDA IDA: Inferred from direct assay	1846292	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IGF1R Protein Structure

Recep_L_domain

Furin-like

Recep_L_domain

fn3

Pkinase_Tyr

0
300
600
900
1200
1367 a.a.

Protein Preferred Names	Protein Names
insulin-like growth factor 1 receptor	IGF-I receptor

IGF1R Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IGF1R	P08069	SHC1	Homo sapiens	P29353-2	Y2H	7541045
Intra	IGF1R	P08069	SHC1	Homo sapiens	P29353-2	Far-WB	7541045
Intra	IGF1R	P08069	TAGLN	Homo sapiens	Q01995	Anti Bait CoIP	22245152
Intra	IGF1R	P08069	CSK	Homo sapiens	P41240	Y2H	10026153
Intra	IGF1R	P08069	CSK	Homo sapiens	P41240	CoIP	10026153
Intra	IGF1R	P08069	CSK	Homo sapiens	P41240	Anti Bait CoIP	10026153
Cross	IGF1R	P08069	Crk	Mus musculus	Q64010	Pull Down	9480911
Intra	IGF1R	P08069	PTPN11	Homo sapiens	Q06124	BioID	35384245
Intra	IGF1R	P08069	PTPN11	Homo sapiens	Q06124	Beta Galactosidase	8895367
Intra	IGF1R	P08069	PTPN11	Homo sapiens	Q06124	Pull Down	7642582
Intra	IGF1R	P08069	PTPN11	Homo sapiens	Q06124	Y2H	8895367
Intra	IGF1R	P08069	PIK3R2	Homo sapiens	O00459	Affinity Chrom	35384245
Intra	IGF1R	P08069	PIK3R2	Homo sapiens	O00459	BioID	35384245
Intra	IGF1R	P08069	YWHAE	Homo sapiens	P62258	Pull Down	9111084
Intra	IGF1R	P08069	INSR	Homo sapiens	P06213	Anti Tag CoIP	34591642
Intra	IGF1R	P08069	INSR	Homo sapiens	P06213	Affinity Chrom	35384245
Intra	IGF1R	P08069	PIK3R1	Homo sapiens	P27986	Pull Down	7642582
Intra	IGF1R	P08069	IGF1R	Homo sapiens	P08069	Anti Tag CoIP	11448933
Intra	IGF1R	P08069	IGF1	Homo sapiens	P05019	H1-H2 MS	21645859
Intra	IGF1R	P08069	YWHAB	Homo sapiens	P31946	Pull Down	9581554
Intra	IGF1R	P08069	YWHAB	Homo sapiens	P31946	Y2H	9581554
Intra	IGF1R	P08069	YWHAB	Homo sapiens	P31946	CoIP	9581554
Intra	IGF1R	P08069	PIK3R1	Homo sapiens	P27986	BioID	35384245
Intra	IGF1R	P08069	PIK3R1	Homo sapiens	P27986	Affinity Chrom	35384245
Intra	IGF1R	P08069	YWHAB	Homo sapiens	P31946	Y2H	15629149
Intra	IGF1R	P08069	IGF1R	Homo sapiens	P08069	Comigration in SDS	21645859
Intra	IGF1R	P08069	IGF1R	Homo sapiens	P08069	GMS	21645859
Intra	IGF1R	P08069	IGF1R	Homo sapiens	P08069	Protein Kinase Assay	17586502
Intra	IGF1R	P08069	IGF1R	Homo sapiens	P08069	SLS	21645859
Intra	IGF1R	P08069	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	22261717
Intra	IGF1R	P08069	P49913-PRO_0000004724	Homo sapiens	P49913-PRO_0000004724	ELISA	21685939
Intra	IGF1R	P08069	ITGB1	Homo sapiens	P05556	Affinity Chrom	35384245
Intra	IGF1R	P08069	KCNIP3	Homo sapiens	Q9Y2W7	Validated Y2H	25416956
Intra	IGF1R	P08069	KCNIP3	Homo sapiens	Q9Y2W7	Y2H Prey Pooling	32296183
Intra	IGF1R	P08069	KCNIP3	Homo sapiens	Q9Y2W7	Validated Y2H	32296183
Intra	IGF1R	P08069	KCNIP3	Homo sapiens	Q9Y2W7	Y2H Array	25416956
Intra	IGF1R	P08069	KCNIP3	Homo sapiens	Q9Y2W7	Y2H Array	32296183
Intra	IGF1R	P08069	PTPN6	Homo sapiens	P29350	Anti Tag CoIP	28065597
Intra	IGF1R	P08069	IGF1	Homo sapiens	P05019	Competition Binding	8452530
Intra	IGF1R	P08069	IGF1	Homo sapiens	P05019	SPR	21645859
Intra	IGF1R	P08069	ARHGEF12	Homo sapiens	Q9NZN5	Imaging	11724822
Intra	IGF1R	P08069	ARHGEF12	Homo sapiens	Q9NZN5	Anti Tag CoIP	11724822
Intra	IGF1R	P08069	ARHGEF12	Homo sapiens	Q9NZN5	Anti Bait CoIP	11724822
Intra	IGF1R	P08069	LEF1	Homo sapiens	Q9UJU2	Anti Tag CoIP	22261717
Intra	IGF1R	P08069	LEF1	Homo sapiens	Q9UJU2	Anti Bait CoIP	22261717
Intra	IGF1R	P08069	PTPN1	Homo sapiens	P18031	BioID	35384245
Intra	IGF1R	P08069	PTPN1	Homo sapiens	P18031	BRET	15976035
Intra	IGF1R	P08069	PPM1A	Homo sapiens	P35813	Anti Tag CoIP	28065597
Cross	IGF1R	P08069	INS	Bos taurus	P01317	Competition Binding	8452530

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IGF1R Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72256	IGF1R/IGF-I R Protein, Human (His)	P08069 (Y763-E931)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P72606	IGF1R/IGF-I R Protein, Human (HEK293, His)	P08069 (E31-N932)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73137	IGF1R/IGF-I R Protein, Human (Active, sf9, His-GST)	P08069 (M954-C1367)	≥ 85%, as determined by reducing SDS-PAGE.
HY-P74442	IGF1R/IGF-I R Protein, Human (HEK293, His, solution)	P08069 (E31-N932)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78142	IGF1R/IGF-I R Protein, Human (Biotinylated, HEK293, His-Avi)	P08069 (E31-N932)	≥ 90%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
HY-P78458	IGF1R/IGF-I R Protein, Human (HEK293, His-Avi)	P08069 (E31-N932)	≥ 95%, as determined by Bis-Tris PAGE.

IGF1R Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80717	IGF1 Receptor Antibody (YA351)	WB, IHC-P	Human
HY-P80717A	IGF1 Receptor Antibody (YA351)(PBS only)	WB, IHC-P	Human
HY-P80825	Phospho-IGF1 Receptor (Tyr1166) Antibody (YA186)	WB, IP	Human, Mouse, Rat
HY-P80825A	Phospho-IGF1 Receptor (Tyr1166) Antibody (YA186)(PBS only)	WB, IP	Human, Mouse, Rat
HY-P85213	IGF1 Receptor Antibody (YA4905)	IHC-P, ELISA	Human
HY-P85214	IGF1 Receptor Antibody (YA4906)	IHC-P, ELISA	Human
HY-P86076	Phospho-IGF1R(Tyr1135/1136)/Insulin Receptor β(Tyr1150/1151) Antibody (YA5768)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86629	IGF1 Receptor Antibody (YA6321)	WB, IHC-P, ICC/IF, IP, ELISA	Human

Related Diseases

Diseases	Alias
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
Rhabdomyosarcoma
Rett Syndrome	Atypical Rett Syndrome RTT Rts Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use Rett Syndrome, Atypical Rett Syndrome, Preserved Speech Variant Rett'S Disorder Rett Syndrome Variant Rett Disorder Cerebroatrophic Hyperammonemia Rett Like Syndrome Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome Rett'S Syndrome Atypical Rtt Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Rett Syndrome Preserved Speech Variant Rett Syndrome Zappella Variant Rett Syndrome, Zappella Variant
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma Primitive Neuroectodermal Tumor ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Ewing Family Of Tumors Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Silver-Russell Syndrome 1	Silver-Russell Syndrome Russell-Silver Syndrome Silver-Russell Dwarfism Rss SRS1 Srs Silver Russell Dwarfism Russell Silver Syndrome Silver Russell Syndrome
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Liposarcoma	Lipomatous Cancer
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Breast Adenocarcinoma	Mammary Adenocarcinoma Adenocarcinoma Of Breast
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Polycythemia Vera	PV Polycythemia Rubra Vera Prv Osler-Vaquez Disease Chronic Erythremia Polycythaemia Rubra Vera Primary Polycythemia Vaquez Disease Polycythemia Vera, Somatic Osler-Vaquez Syndrome Proliferative Polycythaemia Polycythemia Ruba Vera Acquired Primary Erythrocytosis Heilmeyer-Schoner Disease Vaquez Osler Disease Primary Polycythaemia
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Rhabdomyosarcoma 2	Alveolar Rhabdomyosarcoma Rhabdomyosarcoma, Alveolar Rhabdomyosarcoma Alveolar RMS2 Rmsa Rhabdomyosarcoma 2, Alveolar Alveolar Childhood Rhabdomyosarcoma Arms Rhabdomyosarcoma, Type 2
Skeletal Muscle Cancer	Malignant Tumor Of Skeletal Muscle Skeletal Muscle Neoplasm
Embryonal Rhabdomyosarcoma	Rhabdomyosarcoma, Embryonal Rhabdomyosarcoma Embryonal Botryoid Rhabdomyosarcoma Erms Spindle Cell Rhabdomyosarcomas
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Adrenal Cortical Carcinoma	Adrenocortical Carcinoma Adrenal Cortex Carcinoma Carcinoma Of The Adrenal Cortex Acc Adrenocortical Cancer Carcinoma Adrenocortical
Adrenal Carcinoma	Adrenal Cancer Adrenal Gland Cancer Malignant Neoplasm Of Adrenal Gland Adrenal Gland Neoplasms Carcinoma Of The Adrenal Gland Adrenal Neoplasm Malignant Adrenal Tumor Neoplasm Of Adrenal Gland Tumor Of The Adrenal Gland Adrenal Gland Neoplasm Adrenocortical Carcinoma Adrenal Gland Malignancy Suprarenal Cancer Malignant Neoplasm Of Suprarenal Gland Malignant Neoplasm Of Adrenal Gland, Unspecified Malignant Tumour Of Adrenal Gland Suprarenal Gland Cancer Primary Malignant Neoplasm Of Adrenal Gland
Chromosome 15q26-Qter Deletion Syndrome	Drayer Syndrome 15q26 Deletion Syndrome Distal 15q Deletion Syndrome Distal Monosomy 15q Telomeric 15q Deletion Syndrome Monosomy 15q26
Myeloma, Multiple	Multiple Myeloma Kahler Disease Myelomatosis Plasma Cell Myeloma Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler'S Disease Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Nk-Cell Enteropathy
Hyperglycemia
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Adenocarcinoma	Adenocarcinomas Adenoacanthoma Of Unspecified Site Adenocarcinoid Of Unspecified Site Adenocarcinoid Tumour Of Unspecified Site Adenocarcinoma And Carcinoid Combined Of Unspecified Site Adenocarcinoma Nos
Osteogenic Sarcoma	Osteosarcoma OSRC Osteosarcoma, Somatic Neoplasms, Bone Tissue Bone Tissue Neoplasm Osteoid Sarcoma Skeletal Sarcoma Osteosarcoma Of Bone Bone Sarcoma
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Sarcoma, Synovial	Synovial Sarcoma Synovialosarcoma Synovial Cell Sarcoma Sarcoma Synovial
Neuroendocrine Tumor	Neuroendocrine Neoplasm Neuroendocrine Tumors Carcinoma, Neuroendocrine
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Colon Adenocarcinoma	Adenocarcinoma Of Colon Adenocarcinoma Of The Colon Colonic Adenocarcinoma
Thyroid Gland Anaplastic Carcinoma	Anaplastic Thyroid Carcinoma Anaplastic Thyroid Cancer Thyroid Cancer, Anaplastic Thyroid Carcinoma, Anaplastic Thyroid Carcinoma Anaplastic
Muscular Atrophy	Muscle Wasting Amyotrophia Wasting - Muscle Skeletal Muscle Atrophy
Donohue Syndrome	Leprechaunism Leprechaunism Syndrome Donohue'S Syndrome LEPRCH
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Squamous Cell Skin Cancer Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin
Vagina Sarcoma	Sarcoma Of The Vagina Vaginal Sarcoma
Estrogen-Receptor Positive Breast Cancer
Muscle Cancer	Myosarcoma Malignant Neoplasm Of Muscle Malignant Tumor Of Muscle Malignant Tumor Of The Muscle Muscle Neoplasms Myomatous Neoplasm
Aging
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma
Vaginal Endometrial Stromal Sarcoma
Insulin-Like Growth Factor I	Insulin-Like Growth Factor I Deficiency IGF1 DEFICIENCY Insulin-Like Growth Factor I, Resistance To Growth Retardation With Deafness And Mental Retardation Due To Igf1 Deficiency Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency Growth Delay Due To Insulin-Like Growth Factor I Resistance IGF1RES Igf-I Resistance Growth Retardation With Sensorineural Deafness And Mental Retardation Somatomedin, End-Organ Insensitivity To Somatomedin-C Somatomedin-C, Resistance To Insulin-Like Growth Factor 1 Resistance To Igf-1 Resistance Somatomedin End-Organ Insensitivity To Somatomedin-C Resistance To Growth Delay-Deafness-Intellectual Disability Syndrome Growth Delay-Hearing Loss-Intellectual Disability Syndrome Igf-1 Deficiency Primary Insulin-Like Growth Factor Deficiency Resistance To Igf-1 Insulin-Like Growth Factor 1 Resistance End-Organ Insensitivity To Somatomedin Igf1 Resistance Resistance To Insulin-Like Growth Factor I Resistance To Somatomedin-C Insulin-Like Growth Factor 1, Resistance To
Scoliosis
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Beckwith-Wiedemann Syndrome	Wiedemann-Beckwith Syndrome BWS Exomphalos-Macroglossia-Gigantism Syndrome Emg Syndrome Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation Emg Abnormality Wbs Exomphalos Macroglossia Gigantism Syndrome Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation Macroglossia Exomphalos Gigantism
Hyperinsulinism	Hyperinsulinemia
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Lymphangioleiomyomatosis	Lymphangiomyomatosis LAM Lung Lymphangioleiomyomatosis Pulmonary Lymphangioleiomyomatosis Lymphangioleiomyomatosis, Somatic Lymphangio-Myomatosis
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Short Syndrome	Short Stature, Hyperextensibility, Hernia, Ocular Depression, Rieger Anomaly, And Teething Delay Aarskog-Ose-Pande Syndrome Lipodystrophy, Partial, With Rieger Anomaly And Short Stature Lipodystrophy-Rieger Anomaly-Diabetes Syndrome Rieger Anomaly-Partial Lipodystrophy Syndrome Partial Lipodystrophy With Rieger Anomaly And Short Stature Short Stature, Hyperextensibility, Hernia, Ocular Depression, Rieger Anomaly And Teething Delay Growth Retardation-Rieger Anomaly Short Stature-Hyperextensibility-Rieger Anomaly-Teething Delay SHORTS
Exophthalmos	Proptosis
Acanthosis Nigricans	Keratosis Nigricans An
Graves' Disease	Graves Disease Exophthalmic Goiter Basedow'S Disease Grave'S Disease Basedow Disease Toxic Diffuse Goiter Graves' Hyperthyroidism Parry Disease Autoimmune Hyperthyroidism Toxic Multinodular Goiter
Amelogenesis Imperfecta, Type Ig	Enamel-Renal Syndrome Ers Amelogenesis Imperfecta Type 1g AI1G Enamel-Renal-Gingival Syndrome Amelogenesis Imperfecta And Gingival Fibromatosis Syndrome Aigfs Amelogenesis Imperfecta, Hypoplastic, With Nephrocalcinosis Amelogenesis Imperfecta Hypoplastic With Nephrocalcinosis Amelogenesis Imperfecta Type Ig Amelogenesis Imperfecta-Nephrocalcinosis Syndrome Amelogenesis Imperfecta 1g Hypoplastic Amelogenesis Imperfecta With Nephrocalcinosis Amelogenesis Imperfecta Nephrocalcinosis
Paraganglioma And Gastric Stromal Sarcoma	Carney-Stratakis Syndrome Paraganglioma And Gastrointestinal Stromal Tumor Carney Dyad Carney-Stratakis Dyad Of Paraganglioma And Gastric Stromal Sarcoma Paraganglioma And Gist Carney-Stratakis Dyad Gist-Paraganglioma Dyad PGGSS Paraganglioma, Gastric Stromal Sarcoma Gastrointestinal Stromal Tumors
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Laron Syndrome	Growth Hormone Insensitivity Syndrome Growth Hormone Receptor Deficiency Laron Dwarfism Pituitary Dwarfism Ii Laron-Type Isolated Somatotropin Defect Primary Growth Hormone Resistance Laron-Type Dwarfism Laron Type Pituitary Dwarfism I Primary Growth Hormone Insensitivity Primary Gh Resistance Gh-R Deficiency Growth Hormone Receptor Defect Laron-Type Pituitary Dwarfism Laron-Type Short Stature Severe Gh Insensitivity Ghis Short Stature Due To A Defect In Growth Hormone Receptor Or Post-Receptor Pathway Complete Growth Hormone Insensitivity Gh Receptor Deficiency Primary Gh Insensitivity Short Stature Due To Growth Hormone Resistance LARS
Melanoma, Uveal	Uveal Melanoma Choroidal Melanoma Melanoma Of Uvea Iris Melanoma Malignant Melanoma Of Choroid Malignant Melanoma Of Iris
Amelogenesis Imperfecta	Ai Congenital Enamel Hypoplasia Al - [Amelogenesis Imperfecta]
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Hypotrichosis 10	HYPT10
Localized Osteosarcoma	Localised Osteogenic Sarcoma Localised Osteosarcoma Localized Osteogenic Sarcoma
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Pancreatic Adenocarcinoma	Adenocarcinoma Of Pancreas Adenocarcinoma Of The Pancreas Pancreas Adenocarcinoma Malignant Exocrine Neoplasm Primary Pancreatic Adenocarcinoma Adenocarcinoma Of Islet Cell Of Pancreas Islet Cell Adenocarcinoma Of Unspecified Site Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Dedifferentiated Liposarcoma	Ddls Liposarcoma Dedifferentiated Liposarcoma, Dedifferentiated
Diabetes Mellitus	Diabetes
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Adrenal Cortex Disease	Adrenal Cortex Diseases
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Rhabdoid Cancer	Rhabdoid Tumor Malignant Rhabdoid Tumor Malignant Rhabdoid Tumour Rhabdoid Sarcoma Rhabdoid Tumor Predisposition Syndrome 1 Rhabdoid Tumor Predisposition Syndrome 2 Atypical Teratoid Rhabdoid Tumor Brain Tumor, Posterior Fossa, Of Infancy, Familial Atypical Teratoid/Rhabdoid Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15656	Ceritinib	Inhibitor	99.95%	Yes
HY-15656A	Ceritinib dihydrochloride	Inhibitor	99.90%	Yes
HY-B0025	Voglibose	Inhibitor	98.0%	Unkown
HY-15656AR	Ceritinib dihydrochloride (Standard)	Inhibitor	/	Unkown
HY-15656R	Ceritinib (Standard)	Inhibitor	99.72%	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99165	Teprotumumab	Inhibitor	99.46%	Unkown
HY-P990084	Veligrotug		99.25%	Unkown

Clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15494	Picropodophyllin		99.85%	Phase 2
HY-10200	BMS-754807	Inhibitor	99.42%	Phase 2
HY-19565	KW-2450 tosylate		/	Phase 2
HY-B0794B	AZ7550 Mesylate	Inhibitor	98.70%	Phase 1
HY-B0794	AZ7550	Inhibitor	97.09%	Phase 1
HY-15749	XL228	Inhibitor	99.64%	Phase 1
HY-13326	ASP3026		99.88%	Phase 1
HY-B0794A	AZ7550 hydrochloride	Inhibitor	98.66%	Phase 1

Inhibitory Antibodies (8)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99294	Ganitumab	Inhibitor	96.00%	Phase 3
HY-P99197	Figitumumab	Inhibitor	≥99.0%	Phase 3
HY-P99189	Cixutumumab	Inhibitor	99.63%	Phase 2
HY-P99284	Dalotuzumab		97.43%	Phase 2
HY-P99218	Robatumumab	Inhibitor	98.00%	Phase 2
HY-P99712	Lonigutamab		95.00%	Phase 2
HY-P99672	Istiratumab	Inhibitor	98.45%	Phase 2
HY-P991253	BIIB022	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (65)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-113402	Gamma-glutamylcysteine		98.53%	Unkown
HY-116624	MAZ51		99.96%	Unkown
HY-50866	NVP-AEW541		99.92%	Unkown
HY-10262	BMS-536924		99.83%	Unkown
HY-15609	AZD-3463		99.31%	Unkown
HY-13203	NVP-TAE 226		99.77%	Unkown
HY-N7922	Urolithin M5	Inhibitor	97.31%	Unkown
HY-10252	NVP-ADW742		99.30%	Unkown
HY-10253	AG1024		99.50%	Unkown
HY-N0908	Ginsenoside Rg5		99.88%	Unkown
HY-10524	GSK1904529A		99.03%	Unkown
HY-Y1322	Triphenyl phosphate		99.67%	Unkown
HY-113402A	Gamma-glutamylcysteine TFA		96.68%	Unkown
HY-N1990	Gypenoside XLIX		99.88%	Unkown
HY-P5133	Synstatin (92-119)	Inhibitor	97.61%	Unkown
HY-P3226	JB-1		99.63%	Unkown
HY-100349	SU4312	Inhibitor	99.74%	Unkown
HY-P5438	Srctide	Substrate	99.71%	Unkown
HY-135680	I-OMe-Tyrphostin AG 538	Inhibitor	98.03%	Unkown
HY-18785	Indirubin Derivative E804	Inhibitor	98.54%	Unkown
HY-113402R	Gamma-glutamylcysteine (Standard)		98.14%	Unkown
HY-145110	IGF-1R inhibitor-2	Inhibitor	98.36%	Unkown
HY-156914	IGF-1R/SRC-IN-1	Inhibitor	99.86%	Unkown
HY-177760	PrCP-7414		/	Unkown
HY-125102	AZ12253801	Inhibitor	/	Unkown
HY-15656S	Ceritinib-d7	Inhibitor	98.00%	Unkown
HY-113402AR	Gamma-glutamylcysteine TFA (Standard)		/	Unkown
HY-15494R	Picropodophyllin (Standard)		99.70%	Unkown
HY-21291	SU-4313	Modulator	99.31%	Unkown
HY-B0794S	AZ7550-d5	Inhibitor	/	Unkown
HY-N6611	Chimaphilin	Inhibitor	99.80%	Unkown
HY-50866B	NVP-AEW541 dihydrochloride		/	Unkown
HY-100038	AZD9362	Inhibitor	/	Unkown
HY-10252A	cis-NVP-ADW742	Inhibitor	/	Unkown
HY-10438	BMS-577098	Inhibitor	/	Unkown
HY-108230	ALK-IN-12	Inhibitor	/	Unkown
HY-116059	EGFR-IN-199	Inhibitor	/	Unkown
HY-118046	GSK2163632A	Inhibitor	/	Unkown
HY-13312A	GTx-134		/	Unkown
HY-15494S	Picropodophyllin-d3		/	Unkown
HY-15494S1	Picropodophyllin-d6		/	Unkown
HY-15656B	Ceritinib mesylate	Inhibitor	/	Unkown
HY-162506	IGF-1R inhibitor-3	Inhibitor	/	Unkown
HY-167854	KW-2450 free base	Inhibitor	/	Unkown
HY-169572	IGF-1R inhibitor-5	Inhibitor	/	Unkown
HY-169600	IGF-1R inhibitor-4	Inhibitor	/	Unkown
HY-17603A	(E)-Belizatinib	Inhibitor	/	Unkown
HY-177622	Cibrigirsen	Inhibitor	/	Unkown
HY-177622A	Cibrigirsen sodium	Inhibitor	/	Unkown
HY-179732	PROTAC ALK degrader-4		/	Unkown
HY-180972	PROTAC EML4-ALK Degrader-2	Inhibitor	/	Unkown
HY-182264	Masoprocol tetrapivalate	Inhibitor	/	Unkown
HY-183292	SH-1092	Inhibitor	/	Unkown
HY-402309	IGF-1R modulator 1	Modulator	/	Unkown
HY-E70730	INSR Recombinant Human Active Protein Kinase		/	Unkown
HY-RS06615	IGF1R Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06616	Igf1r Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06617	Igf1r Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-100349A	cis-SU4312	Inhibitor	/	Unkown
HY-113402B	Gamma-glutamylcysteine ammonium		/	Unkown
HY-14357	BMS 695735	Inhibitor	/	Unkown
HY-168616	CL-A3-7	Inhibitor	/	Unkown
HY-174654	Human IGF1R mRNA		/	Unkown
HY-174721	Human EGFR mRNA		/	Unkown
HY-W749516	Voglibose-13C3	Inhibitor	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991134	Elegrobart	Inhibitor	95.27%	Unkown
HY-P991255	VRDN-002	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	IGF1R	VGNC	VGNC:67711
Canis familiaris	IGF1R	VGNC	VGNC:41896
Bos taurus	IGF1R	VGNC	VGNC:30077
Macaca mulatta	IGF1R	VGNC	VGNC:82162
Mus musculus	IGF1R	MGD	MGI:96433
Rattus norvegicus	IGF1R	RGD	RGD:2869
Others	IGF1R	NCBI